Multiple bus routes stop near Federation Wharf, with the closest bus stop being at Flinders Street Station, a six-minute walk away. Key bus lines include routes 216, 220, 234, 302, and 304, among others, connecting various suburbs to the city center.

Flinders Street Station, a central hub for all metropolitan train lines, is a four-minute walk from the wharf. Numerous lines, including the Alamein, Craigieburn, Sandringham, Sunbury, and Williamstown routes, converge at this station.

The journey to Federation Wharf can be scenic for those who choose to walk. The area is well-connected by a network of pedestrian paths. The Capital City Trail and the Main Yarra Trail are prominent routes that run along the Yarra River, leading directly to Federation Square and the wharf.

The area is well-connected by a network of cycling paths. The Capital City Trail and the Main Yarra Trail run along the Yarra River, leading directly to Federation Square and the wharf. Bike racks are available in and around Federation Square.

Melbourne River Cruises and City River Cruises explicitly list Berth 2, Federation Wharf as a departure point for their sightseeing tours.

Federation Wharf is accessible via major city roads such as Flinders Street, Swanston Street, Russell Street, and Batman Avenue. Several secure parking options are available nearby, such as Wilson Parking at Federation Square.

Melbourne Water Taxis offer private and public services with pick-up and drop-off points along the river, including at Federation Wharf.

A free Chadstone Tourist Shuttle operates multiple daily services to and from Federation Square, offering a convenient option for shoppers and tourists.

Taxis and ride-sharing services are readily available throughout Melbourne and offer a direct route to the vicinity of Federation Wharf. A convenient drop-off point is the Langham Hotel on the Southbank Promenade, which is a pleasant five-minute walk across the Evan Walker Bridge to Berth 2.